A new cytochrome in liver microsomes.

نویسندگان

  • T OMURA
  • R SATO
چکیده

8. HEPPEL, L. A., in S. P. COLOWICK AND N. 0. KAPLAN (Editors), Methods in enzymology, Vol. II, Academic Press, Inc., New York, 1955, p. 575. CANTONI, G. L., in M. FLORKIN AND H. S. MASON (Editors), Comparative biochemistry, Vol. I, Academic Press, Inc., New York, 1960, p. 181. THEORELL, H., in D. E. GREEN, (Editor), Currents in biochemical Research, Interscience Publishers, Inc., New York, 1956, p. 275. ROBBINS. P. W., AND LIPMANN, F., J. Biol. Chem., 233, 686 (1958): GREENE, R. C., AND DAVIS, N. B., Abstracts of papers of the 139th meeting of the American Chemical Society, St. Louis, March, 1961. GREENE, R. C., AND DAVIS, $7. B., Biochim. et Biophys. Acta, 43, 360 (1960).

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Metabolic activation and DNA adduct formation of Benzo(a) pyrene by adult and newborn rat skin and liver microsomes

Benzo(a) pyrene is a carcinigen polycyclic aromatic hydrocarbon which diffuses into the environment from combustion of organic meterials.based on various epidemiological evidences it is related to lung,skin and liver cancer.mutagenicity,and immunosuppressivety are among important biological effects of Benzo(a) pyrene.after absorbtion and distribution in the body,it undergoes epoxidation by cyto...

متن کامل

MICROSOME-MEDIATED BENZO[A]PYRENE-DNA BINDING AND INHIBITION BY CYTOSOLIC FRACTIONS FROM LIVER AND SKIN OF ADULT AND WEANLING RATS

Biotransformation of benzo[a]pyrene (BaP) in the presence of microsomal fractions derived from liver and epiderm of adult and weanling rats was examined. The aim of this study was to evaluate the effect of age on the capacity of two organs in transformation of BaP. Subcellular fractions were prepared from skin and liver by ultracentrifugation and were used as the source of BaP metabolizing enzy...

متن کامل

Characterization of a Rat Lung Microsomal Fraction Obtained by Sepharose 2B UItrafiitration

A new procedure for obtaining rat lung microsomes essentially free of interfering hemoproteins has been developed. The method includes Sepharose 2B column chromatography of the 12,000 • g supernatant of lung homogehates, followed by ultracentrifugation of the material eluted in the void volume. Microsomes isolated in this manner contain specific levels of cytochromes bs and P-450 and of NADPH-c...

متن کامل

Tolterodine, a new muscarinic receptor antagonist, is metabolized by cytochromes P450 2D6 and 3A in human liver microsomes.

Tolterodine, a new muscarinic receptor antagonist, is metabolized via two pathways: oxidation of the 5-methyl group and dealkylation of the nitrogen. In an attempt to identify the specific cytochrome P450 enzymes involved in the metabolic pathway, tolterodine was incubated with microsomes from 10 different human liver samples where various cytochrome P450 activities had been rank ordered. Stron...

متن کامل

Cytochrome P450 species involved in the metabolism of quinoline.

Quinoline is a hepatocarcinogen in rats and mice and a well-known mutagen in bacteria after incubation with rat liver microsomes. The specific cytochrome P450 enzymes involved in quinoline metabolism in human and rat liver microsomes were determined using cDNA-expressed cytochrome P450s, correlations with specific cytochrome P450-linked monooxygenase activities in human liver microsomes and inh...

متن کامل

The purification and properties of microsomal cytochrome reductase.

In earlier work (1) a DPNH’-specific microsomal cytochrome reductase, liberated by alcohol extraction and partially purified, was identified in liver microsome fractions from rats and rabbits. Microsomal cytochrome, but not cytochrome c, was found to act as electron acceptor in the oxidation of DPNH catalyzed by the enzyme. Through a rapid cytochrome to cytochrome reaction, cytochrome c was red...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • The Journal of biological chemistry

دوره 237  شماره 

صفحات  -

تاریخ انتشار 1962